【900～1100万円】Scientist II ・ Oncology Safety Assessment

【求人No NJB2369011】
（雇入れ直後）
・Act as an outstanding scientist of discovery safety team.
・Provide scientific and strategic direction to optimize drug candidates for efficacy safety and ADME properties from Safety perspective for Pre DC and DC programs.
・Responsible for the analysis interpretation integration and reporting of preclinical safety data.
・As part of the integrated teams design and execute preclinical studies to understand safety properties combined with pharmacokinetics （PK） and pharmacodynamics （PD）.
・Clarify safety profiles to optimize compounds based on their safety profiles requirements ensuring alignment with program timelines and regulatory standards.
・Interact/manage external vendors （CROs academic sites etc.） for conducting in vivo and in vitro experiments.
・Align with overall Oncology Research strategy and objectives.
・Partner with other functions in Oncology Research as well as Development and Product Research Development members to translate scientific insights into actionable ADME/safety/formulation strategies.

（変更の範囲）
会社内での全ての業務

【就業環境に関する要件 / Specific Physical or Environmental Requirements】
・This position is based in Japan and requires occasional overseas/domestic business travels.
・At Astellas we recognize the importance of work/life balance and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines.

【応募要件 / Qualifications】
＜必須 / Required＞
・Advanced degree （Master degree or Ph.D. or equivalent） in Pharmaceutical Sciences Pharmacology Veterinary science or a related field.
・8 years of experience in pharmaceutical or biotech industry with a focus on safety preferably within oncology or a related therapeutic area.
・Demonstrated leadership competencies in exploratory safety activities from planning implementation through completion across multiple programs
・Communication skills （active passive） in own language and in English.

＜歓迎 / Preferred＞
・External scientific network and reputation demonstrated by patents publications and presentations.
・Experience in oncology drug development and familiarity with the unique challenges of targeting cancer therapeutics.
・Extensive experience in safety assessment with multiple therapeutic modalities （e.g. engineered small molecules peptides ADCs multifunctional antibodies）.
・Demonstrated expertise in developing and implementing safety screening methods and establishing SARs for small molecule antibody and ADC.